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  1. #1
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    E-Cigs as a smoking cessation aid

    Let's look at what has been done so far...

    1. Michael Siegal at Boston University - Survey - 222 respondents
    http://www.ajpmonline.org/article/S0...792-0/abstract

    "Findings suggest that e-cigarettes may hold promise as a smoking-cessation method and that they are worthy of further study using more-rigorous research designs."

    2. South Africa: "E-ciggies help 45% smokers quit"
    http://www.news24.com/SciTech/News/E...-quit-20090807

    "Forty-five percent of South African smokers who used e-cigarettes were able to quit tobacco smoking within two months, a new SA study shows."

    3. Health NZ - "Effect of an E-Cigarette on Cravings and Withdrawal, Acceptability
    and Nicotine Delivery: Randomised Cross-Over Trial."
    http://www.healthnz.co.nz/ecig_effect-2.pdf

    "Over 60 minutes participants using the 16mg EC experienced significantly less craving than when using the placebo EC (mean difference 0.82; 95% C.I. 0.25–1.38; p=0.0061). Cigarette use reduced craving more than the 16mg (difference 1.44; 95% CI 0.39 to 2.48) and 0mg (difference 2.23; 95% CI 1.17 to 3.30). ECs and Nicorette® inhalator (difference 1.54 95% CI 0.48 to 2.59) over the same period. Compared"

    4. Currently under way (and this one is a bit more interesting and it will be on the Australian and New Zealand Clinical Study Register, so it should have to be accepted here)
    http://www.ctru.auckland.ac.nz/index...cotine-devices

    And release online last night, the pièce de résistance...

    5. Institute of Social and Preventive Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland - Survey - 3587 participants
    "Electronic cigarette: users profile, utilization, satisfaction and perceived efficacy"
    http://onlinelibrary.wiley.com/doi/1...505.x/abstract

    "E-cigarettes were used much as people would use nicotine replacement medications: by former smokers to avoid relapse or as an aid to cut down or quit smoking. Further research should evaluate the safety and efficacy of e-cigarettes for administration of nicotine and other substances, and for quitting and relapse prevention."

    Several of these papers state the usual "more research is needed" line and the references to safety and quality is a reasonable concern before products are available for local retail sale, but it pretty much shoots down in flames any anti-tobacco arguments that "they don't work".

    Retailers might not be able to SAY it's a cessation aid due to legal reasons, but there is no longer any doubt (not that there was any amongst the vaping community) - e-cigs work!

  2. #2
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    Well done!

    Number 5 looks particularly promising!
    CO, Vapers Against Government Interference in Nictotine Acquisition - Military Wing.

  3. #3
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    Bloody well done sas!
    If S2 is the route peeps want to go, it'll need evidence of therapeutic value ('cause things won't get classified pharmacist medicines otherwise).

    I swear you've got some kind of time doubler tucked up your sleeve!

    Do you want the full/actual studies? Publishing them to your website would depend on their copyrights, but you could use them in any letters etc. If so, I'll try and pull them tomorrow. Primary sources are always better. (I want to look at them anyways, but prob wouldn't get to them for a few days at least, on my own)

  4. #4
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    That would be awesome

    I'd be interested to read them myself to try and preempt whatever possible "flaws" there might be in the methodology. Having them on hand would also be extremely helpful when talking to different health bodies too.

  5. #5
    Sik
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    Seems the media has picked up on Number 5

    http://www.acsh.org/factsfears/newsI...ews_detail.asp

    http://tobaccoanalysis.blogspot.com/...ands-of-e.html

    "Given these findings, along with previous data from other surveys and anecdotal evidence from numerous other sources, the claim that electronic cigarettes are completely ineffective in smoking cessation because they do not deliver nicotine effectively is now untenable."
    Current Vape: Variable Wattage mod, EPM Boge tanks, Something Fruity

  6. #6
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    Oh, now that's a nice quote!

    I've found the article - it's an accepted but not yet published one to the journal. I think I've seen already published articles on the survey it refers to on my travels finding the others (and where they lead me). If anyone's keen they could try PubMed to see if there's anything publicly available. I'd forgotten about PubMed - it's a U.S. site; acts as a kind of collecting house for freely available medically related docs. (I can't while I'm logged in to databases)
    http://www.ncbi.nlm.nih.gov/pubmed

    Try author searches, &/or a quote or two from the abstract (remove 'the' 'or' etc.... 'and' can be ok, but will limit the search to docs with both words before and after it). Chris Bullen, the NZ researcher, has also done a few studies relating to NRT & e-cigs, including one on safety of Ruyan devices. IHaven't followed up others.

    On number 4)....
    The Aus/NZ Clinical Trials Registry Page link for the study: http://www.anzctr.org.au/trial_view.aspx?ID=336091
    - Seems the trial isn't underway yet, it's still showing as before an ethics committee (no human trial in Aus (don't know but assume NZ is same) can start without it).
    - ANZCTR is a WHO recognised trials registry. Since 2005 all studies need to be registered with a WHO recognised trials registry in order to be published by medical/scientific journals (it was the journals themselves that proposed this)
    - The lead researcher on this, Chris Bullen, has published several articles on smoking cessation/NRT/harm reduction, including specific to e-cigs.

    Here's Chris Bullen's Declaration of Interests statement from No 5's paper;
    "Chris Bullen’s salary is paid by The University of Auckland and his research is supported by grants from the New Zealand Health Research Council (HRC), the University of Auckland and the NZ Heart Foundation. He has previously undertaken tobacco control research supported by the New Zealand Ministry of Health, and by Niconovum, Sweden, prior to the purchase of this company by RJ Reynolds. He is currently an investigator on a study involving reduced nicotine cigarettes in which the products were purchased by the University of Auckland from Vector Group Ltd, USA. He has previously undertaken research on ENDS funded by HealthNZ, in which the study products were supplied by Ruyan, Hong Kong; and he is the principal investigator on an HRC-funded efficacy trial of ENDS that will use products provided by a NZ-based ENDS retailer."

    *sigh* Note the funding on 4 & 5? NZ Health?
    We're so far behind.

    Edit: my error - HealthNZ is apparently a private organisation. (NZ Health Research Council is govt)
    Last edited by vapidkitty; 04-08-11 at 06:34 PM.

  7. #7
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    Found a similar article one of the authors, J.F. Etter, has individually authored. It's available free on BioMed Central's Open Access: http://www.biomedcentral.com/1471-2458/10/231

    The conclusons are worded a little differently, so here's a cut and paste of of 5's (the multi author article).

    "CONCLUSIONS: E-cigarettes were used mainly by former smokers as an aid to quit smoking and avoid relapse. These products were perceived as satisfactory, useful and efficacious, and almost all users preferred nicotine-containing e-cigarettes. Despite its limitations, this study adds to the still small body of knowledge about e-cigarettes and provides valuable additional information for smokers, clinicians, regulators and policy makers. Further research should address the safety and efficacy of using e-cigarettes to deliver nicotine and other substances, and assess their effectiveness as an aid to quitting and relapse prevention."

    vs Etter:
    "Our results suggest that ecigarettes are used mainly to quit smoking, and may be useful for this purpose. However, users were concerned about the potential toxicity of these devices. Very few studies have investigated ecigarettes and research is now urgently required, particularly to establish the efficacy and toxicity of these devices."

 

 

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