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Thread: Nicotine absorption : comparison between first and new-generation devices

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    Nicotine absorption : comparison between first and new-generation devices

    http://www.nature.com/srep/2014/1402...srep04133.html

    A wide range of electronic cigarette (EC) devices, from small cigarette-like (first-generation) to new-generation high-capacity batteries with electronic circuits that provide high energy to a refillable atomizer, are available for smokers to substitute smoking. Nicotine delivery to the bloodstream is important in determining the addictiveness of ECs, but also their efficacy as smoking substitutes. In this study, plasma nicotine levels were measured in experienced users using a first- vs. new-generation EC device for 1 hour with an 18 mg/ml nicotine-containing liquid. Plasma nicotine levels were higher by 35–72% when using the new- compared to the first-generation device. Compared to smoking one tobacco cigarette, the EC devices and liquid used in this study delivered one-third to one-fourth the amount of nicotine after 5 minutes of use. New-generation EC devices were more efficient in nicotine delivery, but still delivered nicotine much slower compared to tobacco cigarettes. The use of 18 mg/ml nicotine-concentration liquid probably compromises ECs' effectiveness as smoking substitutes; this study supports the need for higher levels of nicotine-containing liquids (approximately 50 mg/ml) in order to deliver nicotine more effectively and approach the nicotine-delivery profile of tobacco cigarettes.

    In a nature paper too! Hoorah
    margyb, mathsguy, lozza 82 and 6 others like this.

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    That's a pretty good in depth study mav

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    Great to see this in a well respected mainstream periodical like Nature! Interesting that the 1/4 − 1/3 factor of delivery is in line with the vaping hive mind too.

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    Very fine and credible journal is Nature, great find Mav

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    Quote Originally Posted by mavinry4 View Post
    The use of 18 mg/ml nicotine-concentration liquid probably compromises ECs' effectiveness as smoking substitutes; this study supports the need for higher levels of nicotine-containing liquids (approximately 50 mg/ml) in order to deliver nicotine more effectively and approach the nicotine-delivery profile of tobacco cigarettes.[/B]
    NJoy figured that out already. They use 45mg nicotine strength in their cigalikes, and they certainly give the closest thing to a cigarette experience I've tried.

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    Additionally, plasma nicotine levels after smoking one tobacco cigarette are almost equal to the values after using the new-generation device for 35 minutes (18.52 ng/ml), while they are 73% higher compared to the values after using the first-generation device for 35 minutes (10.88 ng/ml).
    Nice
    I'm not getting into this discussion again


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    And the EU have just limited juice to 20mg/ml




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    Quote Originally Posted by Altered1 View Post
    And the EU have just limited juice to 20mg/ml
    and possibly limit to 1st gen via the 'consistent delivery' requirement. Even though no device does this, they can always do research on 1st gen and say it does


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    whats the bet Euro juice will soon come filled with 'enhancers' to increase the nic absorbtion?




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    Quote Originally Posted by Altered1 View Post
    whats the bet Euro juice will soon come filled with 'enhancers' to increase the nic absorbtion?
    Would never be allowed. ciggies contain this but an isolated compound placed into ejuice would never be approved. Which is bizarre that no one ever made a fuss about this and ciggies.


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